MO989STUDY OF PHARMACOGENETICS OF MYCOFENOLATE MOFETIL IN KIDNEY TRANSPLANT RECIPIENTS: EXPERIENCE OF SAHLOUL HOSPITAL
نویسندگان
چکیده
Abstract Background and Aims The pharmacokinetics pharmacodynamics of the immunosuppressive drug mycophenolate mofetil (MMF) are subject to significant interindividual variability that affects its efficacy toxicity. present study focused on genetic factors potentially involved in response this kidney transplantation, while taking into account influence non-genetic factors. Method 276 transplant patients treated with MMF were involved, recruited from Nephrology transplantion Department Sahloul Hospital. Data exposure clinical outcomes collected. A PCR-RFLP 9 polymorphisms UGT, SLCO IMPDH was performed. Were studied relationship between MMF, risk acute chronic rejection graft, as well adverse effects MMF. Results This showed variant alleles UGT1A9 -2152C>T II 3757T>C would increase rejection. allele SLCO1B1 388A>G protect against 98T>C polymorphism diarrhea, unlike -275T>A polymorphism, which appears be a protective factor diarrhea. UGT1A8 518C>G infections. However, not demonstrated. Conclusion These results highlight need take predicting therapeutic before initiating treatment. Acute SNP Genotype
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چکیده پایان نامه (شامل خلاصه، اهداف، روش های اجرا و نتایج به دست آمده): کار جمع آوری گو یش های محلی در سال های اخیر شتاب امیدوار کننده ای به خود گرفته است. شاید از بارزترین اهداف جمع آوری گویش های مختلف، ثبت و ضبط آن، جلوگیری از نابودی و مهمتر از همه حل مشکلات دستوری زبان رسمی باشد. دقت در فرآیند های زبانی گویش های محلی نوع ارتباط مردم نواحی مختلف با پیرامون نشان را به ما نشان خواهد داد. از س...
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ژورنال
عنوان ژورنال: Nephrology Dialysis Transplantation
سال: 2021
ISSN: ['1460-2385', '0931-0509']
DOI: https://doi.org/10.1093/ndt/gfab111.0013